Far from equilibrium thermodynamics provides a foundation for understanding life, evolution, and the unique role played by the endocannabinoid system in these processes. The metabolic underpinnings of life can be regulated by cannabinoids in order to promote health and longevity. They do so by regulating the negative effects of excess free radical production through their ability to control fat and carbohydrate metabolism. An increase in cannabinoid activity is necessary for the health modern man and human society. Marijuana has become an essential nutrient.